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Sodium butyrate exerts antioxidant stress effects and attenuates Aß25-35-induced cytotoxicity in PC12 cells.
Yuan, Boyu; Liu, Mingming; Gong, Yuhong; Wang, Zifan; Jin, Xinxin; Xie, Gaijie; Zhu, Mingqiang; Zhang, Xue; Luo, Siyuan; Qu, Qing; Zhu, Yufeng; Wang, Meng; Jin, Yingli; Li, Bai; Wang, Wei.
Afiliação
  • Yuan B; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China; Department of Pharmacology, College of Basic Medical Science, Jilin University, Changchun, 130021, China; Guangdong Laboratory fo
  • Liu M; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
  • Gong Y; Laboratory Animal Center of Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
  • Wang Z; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
  • Jin X; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
  • Xie G; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
  • Zhu M; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
  • Zhang X; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
  • Luo S; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
  • Qu Q; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
  • Zhu Y; Laboratory Animal Center of Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
  • Wang M; Bureau of Agriculture and Rural Affairs of Conghua District, Guangzhou, 510900, China.
  • Jin Y; Department of Pharmacology, College of Basic Medical Science, Jilin University, Changchun, 130021, China. Electronic address: jinyingli@jlu.edu.cn.
  • Li B; First Clinical Hospital of Jilin University, Changchun, 130021, China. Electronic address: li_bai@jlu.edu.cn.
  • Wang W; Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China. Electronic address: wang_wei99@jlu.edu.cn.
Arch Biochem Biophys ; 731: 109448, 2022 11 30.
Article em En | MEDLINE | ID: mdl-36306919
Alzheimer's disease (AD), a common neurodegenerative disease, is characterised by the deposition of amyloid-ß (Aß) plaques and neurofibrillary tangles. An increasing number of studies have demonstrated that Aß causes neuronal damage and mitochondrial dysfunction. Herein, we evaluated the neuroprotective effect of sodium butyrate (NaB) against Aß induced neurotoxicity in PC12 cells. The results revealed that 3 mM of NaB promoted the expression of angiotensin-converting enzyme and brain-derived neurotrophic factor, which exert a neuroprotective effect by activating G protein-coupled receptors. Moreover, NaB could significantly improve mitochondrial dysfunction caused by Aß. In conclusion, NaB protected PC12 cells from Aß-induced cell damage, highlighting the potential of NaB in AD treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Doenças Neurodegenerativas / Doença de Alzheimer Limite: Animals Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Doenças Neurodegenerativas / Doença de Alzheimer Limite: Animals Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos