Terpenoids and Phenylpropanoids Isolated from the Twigs and Leaves of Abelia macrotera and Their Anti-Inflammatory Activities.
Chem Biodivers
; 19(12): e202200870, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36317819
ABSTRACT
A new triterpenoid, 3ß-hydroxyurs-12-en-28,20ß-olide (1), as well as thirteen known terpenoids (2-14) and three known phenylpropanoids (15-17), were isolated from the twigs and leaves of Abelia macrotera. Compounds 2, 5-17 were isolated for the first time from the Abelia genus. The structure of compound 1 was determined using the characteristic spectral data (HR-ESI-MS, UV, 1D and 2D-NMR, and X-ray single-crystal diffraction. Furthermore, the inhibitory effects of all compounds on NO production in LPS-induced RAW 264.7 cells were tested, and compound 15 showed obvious inhibitory effect, with IC50 values of 23.77±1.61â
µM. Through target screening and molecular docking technology, it can be speculated that compound 15 may play an anti-inflammatory role by combining with Cathepsinâ
G & Chymase and HPG D.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Triterpenos
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China