A tetravalent peptide that binds to the RANK-binding region of TRAF6 via a multivalent interaction efficiently inhibits osteoclast differentiation.

Anzai, Masataka; Watanabe-Takahashi, Miho; Kawabata, Hiroshi; Mizuno, Saori; Taguchi, Yuu; Inoue, Jun-Ichiro; Nishikawa, Kiyotaka

Anzai, Masataka; Watanabe-Takahashi, Miho; Kawabata, Hiroshi; Mizuno, Saori; Taguchi, Yuu; Inoue, Jun-Ichiro; Nishikawa, Kiyotaka.

Afiliação

Anzai M; Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.
Watanabe-Takahashi M; Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.
Kawabata H; Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.
Mizuno S; Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.
Taguchi Y; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
Inoue JI; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan; Research Platform Office, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
Nishikawa K; Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan. Electronic address: knishika@mail.doshisha.ac.jp.

Biochem Biophys Res Commun ; 636(Pt 1): 178-183, 2022 12 25.

Article em En | MEDLINE | ID: mdl-36334442

Assuntos

Ligante RANK; Fator 6 Associado a Receptor de TNF; Fator 6 Associado a Receptor de TNF/metabolismo; Receptor Ativador de Fator Nuclear kappa-B/metabolismo; Ligante RANK/metabolismo; Osteoclastos/metabolismo; NF-kappa B/metabolismo; Peptídeos/farmacologia; Peptídeos/metabolismo; Diferenciação Celular/fisiologia

Palavras-chave

Multivalent interaction; Osteoclast differentiation; RANK; TRAF6; Tetravalent peptide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 6 Associado a Receptor de TNF / Ligante RANK Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos

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