Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics.

ABSTRACT

ABBREVIATIONS CE-SDS capillary electrophoresis sodium dodecyl sulfate; DSC differential scanning calorimetry; FACS fluorescence-activated cell sorting; FSA full-sized antibody; Her2 human epidermal growth factor receptor 2; MFI mean fluorescent intensity; OAA one-armed antibody; PBS phosphate-buffered saline; PDB Protein Data Bank; SEC size-exclusion chromatography; prepSEC (preparative SEC); RMSD root-mean-square deviation; RU resonance units; SPR surface plasmon resonance; TAA tumor-associated antigen; WT wild-type.