[Immunological mechanisms of cognitive dysfunction under systemic therapy in metastatic melanoma]. / Kognitive Funktionsstörungen unter Systemtherapie bei metastasiertem Melanom.
Dermatologie (Heidelb)
; 73(12): 937-942, 2022 Dec.
Article
em De
| MEDLINE
| ID: mdl-36350371
ABSTRACT
Neurocognitive impairments of memory, speech, and attention can occur in cancer patients as a direct result of the cancer but also in the context of therapy. With the development of modern immunotherapies and their use in combination with surgery and radiation therapy, the number of long-term survivors has significantly increased. As a result, detrimental effects on brain function and structure in cancer patients not only during treatment but also after completion of therapy have become a key issue in clinical oncology. Early diagnosis and treatment of neurocognitive disorders is of great importance for quality of life, therapy adherence, and overall survival of the affected patients. In this review, we discuss the underlying mechanisms with a special focus on metastatic melanoma. Furthermore, practice-relevant diagnostics, prophylaxis, and intervention options are discussed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Segunda Neoplasia Primária
/
Disfunção Cognitiva
/
Melanoma
Tipo de estudo:
Etiology_studies
/
Screening_studies
Aspecto:
Patient_preference
Limite:
Humans
Idioma:
De
Revista:
Dermatologie (Heidelb)
Ano de publicação:
2022
Tipo de documento:
Article