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Morphological Assessment and Biomarkers of Low-Grade, Chronic Intestinal Inflammation in Production Animals.
Soares, Igor; Belote, Bruna L; Santin, Elizabeth; Dal Pont, Gabriela C; Kogut, Michael H.
Afiliação
  • Soares I; ISI Institute, Cambé, Parana 86187-025, Brazil.
  • Belote BL; ISI Institute, Cambé, Parana 86187-025, Brazil.
  • Santin E; ISI Institute, Cambé, Parana 86187-025, Brazil.
  • Dal Pont GC; Department of Poultry Science, Texas A&M University, College Station, TX 77843, USA.
  • Kogut MH; Southern Plains Agricultural Research Center, United States Department of Agriculture-Agricultural Research Service (USDA-ARS), College Station, TX 77845, USA.
Animals (Basel) ; 12(21)2022 Nov 04.
Article em En | MEDLINE | ID: mdl-36359160
ABSTRACT
The complex interaction between the intestinal mucosa, the gut microbiota, and the diet balances the host physiological homeostasis and is fundamental for the maximal genetic potential of production animals. However, factors such as chemical and physical characteristics of the diet and/or environmental stressors can continuously affect this balance, potentially inducing a state of chronic low-grade inflammation in the gut, where inflammatory parameters are present and demanding energy, but not in enough intensity to provoke clinical manifestations. It's vital to expand the understanding of inflammation dynamics and of how they compromise the function activity and microscopic morphology of the intestinal mucosa. These morphometric alterations are associated with the release of structural and functional cellular components into the feces and the blood stream creating measurable biomarkers to track this condition. Moreover, the identification of novel, immunometabolic biomarkers can provide dynamic and predictors of low-grade chronic inflammation, but also provide indicators of successful nutritional or feed additive intervention strategies. The objective of this paper is to review the mechanisms of low-grade inflammation, its effects on animal production and sustainability, and the biomarkers that could provide early diagnosis of this process and support studies of useful interventional strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Screening_studies Idioma: En Revista: Animals (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Screening_studies Idioma: En Revista: Animals (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil