High serum ß2-microglobulin is a significant predictor of mortality in maintenance hemodialysis patients.
Semin Dial
; 36(3): 247-254, 2023.
Article
em En
| MEDLINE
| ID: mdl-36372394
ABSTRACT
BACKGROUND:
Beta2-microglobulin, a novel marker of kidney function, predicts kidney failure and mortality in the general population. However, few studies have evaluated the association of serum ß2-MG level with clinical outcome in maintenance hemodialysis (MHD) patients.METHODS:
This prospective cohort study enrolled 303 MHD patients to investigate the factors related to ß2-MG and its relationship to mortality in MHD patients. Multivariate linear regression analysis was used to examine the factors related to ß2-MG level. Multivariable Cox regression was used to calculate the hazard ratios for ß2-MG on all-cause and cardiovascular mortality.RESULTS:
The median value of serum ß2-MG was 44.6 mg/L (interquartile range 37.60-50.40 mg/L). During the follow-up period of 24 months, there were 48 all-cause deaths (23.0%), including 36 cardiovascular causes (75.0% of all deaths). Multiple linear regression showed that dialysis duration, serum creatinine, and alkaline phosphatase were independent predictors of serum ß2-MG level. Kaplan-Meier analysis revealed that mortality in MHD patients was significantly higher in low albumin patients with ß2-MG > 44.6 mg/L. Cox regression analysis showed that ß2-MG was a significant predictor of all-cause mortality (HR = 1.122, 95% CI 1.058-1.190, ð < 0.001) and cardiovascular mortality (HR = 1.145, 95%CI 1.065-1.123, P < 0.001) in MHD patients with low albumin level after adjusting for confounding factors. However, our results showed that serum ß2-MG was not associated with mortality in MHD patients with normal albumin level.CONCLUSION:
These results are supportive of the potential role of the serum ß2-MG level as a predictor of mortality in MHD patients with low albumin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Falência Renal Crônica
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Semin Dial
Assunto da revista:
NEFROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China