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Residential greenness and dyslipidemia risk: Dose-response relations and mediation through BMI and air pollution.
Wang, Qinjian; Li, Xiaoqing; Zhong, Wenling; Liu, Hongyun; Feng, Chuanteng; Song, Chao; Yu, Bin; Fu, Yao; Lin, Xi; Yin, Yanrong; Chen, Tiehui; Reinhardt, Jan D; Yang, Shujuan.
Afiliação
  • Wang Q; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
  • Li X; Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
  • Zhong W; Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
  • Liu H; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
  • Feng C; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Institute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Chengdu, China.
  • Song C; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
  • Yu B; Institute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Chengdu, China.
  • Fu Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
  • Lin X; Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
  • Yin Y; Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
  • Chen T; Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
  • Reinhardt JD; Institute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Chengdu, China; Department of Rehabilitation Medicine, Jiangsu Province Hospital/Nanjing Medical University First Affiliated Hospital, Nanjing, China; Swiss Paraplegic Research, Nottwil, Sw
  • Yang S; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Department of Health Management Center, Clinical Medical College & Affiliated Hospital, Chengdu University, Chengdu, China; International Institute of Spatial Lifecourse Epidemiology (ISLE), Wu
Environ Res ; 217: 114810, 2023 01 15.
Article em En | MEDLINE | ID: mdl-36395867
BACKGROUND: Evidence on associations of residential greenness with dyslipidemia is limited, particularly regarding dose-response relations and mediation. OBJECTIVES: To investigate associations between greenness and dyslipidemia, non-linear dose-response relationships and mediators. METHODS: This cross-sectional study draws on the 2018 Fujian Behavior and Disease Surveillance (FBDS) cohort that used multi-stage stratified random sampling from the general population of Fujian Province, China. Participants with one or more abnormities in total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), or low-density lipoprotein cholesterol (LDL-C) were classified as having dyslipidemia. Residential greenness was operationalized as 3-year average of the normalized difference vegetation index (NDVI500m) and enhanced vegetation index (EVI500m). A doubly robust approach was used for effect quantification. Dose-response relations were studied with natural cubic splines. Mediation via physical activity (PA), body mass index (BMI), PM2.5, PM10, SO2, and NO2 was also examined. RESULTS: Data from 43,183 participants were analyzed. Increases in NDVI500m and EVI500m residential greenness were associated with decreased dyslipidemia risk and improved blood lipids. Non-linear dose response relationships were discovered. Significant reduction of dyslipidemia risk was observed at levels of EVI500m > 0.48 and NDVI500m > 0.65. Joint mediation effects of PA, BMI, PM2.5, PM10, NO2, and SO2 on the associations of NDVI500m and EVI500m with dyslipidemia risk were 49.74% and 44.64%, respectively. CONCLUSIONS: Increased residential exposure to greenness was associated with decreased risk of dyslipidemia. A non-linear dose-response relationship between greenness and dyslipidemia suggests that specific thresholds of greenness need to be reached in order to achieve effects. BMI, PM2.5, and PM10 partially mediated the association.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluição do Ar / Dióxido de Nitrogênio Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Environ Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluição do Ar / Dióxido de Nitrogênio Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Environ Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Holanda