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Mycobiota and diet-derived fungal xenosiderophores promote Salmonella gastrointestinal colonization.
Santus, William; Rana, Amisha P; Devlin, Jason R; Kiernan, Kaitlyn A; Jacob, Carol C; Tjokrosurjo, Joshua; Underhill, David M; Behnsen, Judith.
Afiliação
  • Santus W; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA.
  • Rana AP; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA.
  • Devlin JR; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA.
  • Kiernan KA; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA.
  • Jacob CC; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA.
  • Tjokrosurjo J; Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA, USA.
  • Underhill DM; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Behnsen J; F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Nat Microbiol ; 7(12): 2025-2038, 2022 12.
Article em En | MEDLINE | ID: mdl-36411353
ABSTRACT
The fungal gut microbiota (mycobiota) has been implicated in diseases that disturb gut homeostasis, such as inflammatory bowel disease. However, little is known about functional relationships between bacteria and fungi in the gut during infectious colitis. Here we investigated the role of fungal metabolites during infection with the intestinal pathogen Salmonella enterica serovar Typhimurium, a major cause of gastroenteritis worldwide. We found that, in the gut lumen, both the mycobiota and fungi present in the diet can be a source of siderophores, small molecules that scavenge iron from the host. The ability to use fungal siderophores, such as ferrichrome and coprogen, conferred a competitive growth advantage to Salmonella strains expressing the fungal siderophore receptors FhuA or FhuE in vitro and in a mouse model. Our study highlights the role of inter-kingdom cross-feeding between fungi and Salmonella and elucidates an additional function of the gut mycobiota, revealing the importance of these understudied members of the gut ecosystem during bacterial infection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sideróforos / Microbioma Gastrointestinal Limite: Animals Idioma: En Revista: Nat Microbiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sideróforos / Microbioma Gastrointestinal Limite: Animals Idioma: En Revista: Nat Microbiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos