Multiple Mutations on &#945;, ß and Î³ Domains of Streptokinase Lead to the Generation of Highly Efficient Cysteine Analogues with Promising Features.

Alinodehi, Narges Norouzzadeh; Behrooz, Hamideh; Sabaei, Milad; Nezamiha, Farahnaz Khoshdel; Mianroodi, Reza Arabi

Multiple Mutations on α, ß and Î³ Domains of Streptokinase Lead to the Generation of Highly Efficient Cysteine Analogues with Promising Features.

Alinodehi, Narges Norouzzadeh; Behrooz, Hamideh; Sabaei, Milad; Nezamiha, Farahnaz Khoshdel; Mianroodi, Reza Arabi.

Afiliação

Alinodehi NN; Department of Genetics and Biotechnology, Faculty of Biological Science, Varamin-Pishva Branch, Islamic Azad, Varamin, Iran.
Behrooz H; Biotechnology Department, Faculty of Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran.
Sabaei M; Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
Nezamiha FK; R&D Department, Research and production complex, Pasteur Institute of Iran, Tehran, Iran.
Mianroodi RA; R&D Department, Research and production complex, Pasteur Institute of Iran, Tehran, Iran.

Curr Pharm Biotechnol ; 24(10): 1326-1334, 2023.

Article em En | MEDLINE | ID: mdl-36424778

Assuntos

Cisteína; Estreptoquinase; Estreptoquinase/genética; Estreptoquinase/metabolismo; Cisteína/genética; Plasminogênio/química; Plasminogênio/genética; Plasminogênio/metabolismo; Fibrinolíticos; Mutação

Palavras-chave

Streptokinase; activity; cysteine; docking; plasminogen; site directed mutagenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estreptoquinase / Cisteína Idioma: En Revista: Curr Pharm Biotechnol Assunto da revista: BIOTECNOLOGIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã País de publicação: Holanda

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