Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of <i>Trypanosoma brucei rhodesiense</i>.

Di Chio, Carla; Previti, Santo; De Luca, Fabiola; Bogacz, Marta; Zimmer, Collin; Wagner, Annika; Schirmeister, Tanja; Zappalà, Maria; Ettari, Roberta

Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense.

Di Chio, Carla; Previti, Santo; De Luca, Fabiola; Bogacz, Marta; Zimmer, Collin; Wagner, Annika; Schirmeister, Tanja; Zappalà, Maria; Ettari, Roberta.

Afiliação

Di Chio C; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
Previti S; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
De Luca F; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
Bogacz M; Institute of Organic Chemistry & Macromolecular Chemistry, Friedrich-Schiller University of Jena, Humboldtstraße 10, 07743 Jena, Germany.
Zimmer C; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudingerweg 5, 55128 Mainz, Germany.
Wagner A; Institute of Organic Chemistry & Macromolecular Chemistry, Friedrich-Schiller University of Jena, Humboldtstraße 10, 07743 Jena, Germany.
Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudingerweg 5, 55128 Mainz, Germany.
Zappalà M; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
Ettari R; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

Int J Mol Sci ; 23(22)2022 Nov 21.

Article em En | MEDLINE | ID: mdl-36430948

Assuntos

Curcumina; Trypanosoma brucei rhodesiense; Humanos; Curcumina/farmacologia; Dipeptídeos; Nitrilas; Cisteína Endopeptidases; Combinação de Medicamentos; Antígeno CD24

Palavras-chave

combination studies; curcumin; cysteine protease; dipeptide nitrile; rhodesain inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma brucei rhodesiense / Curcumina Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália País de publicação: Suíça

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