Sustained delivery of CpG oligodeoxynucleotide by acetalated dextran microparticles augments effector response to Computationally Optimized Broadly Reactive Antigen (COBRA) influenza hemagglutinin.

Batty, Cole J; Amouzougan, Eva A; A Carlock, Michael; Ross, Ted M; Bachelder, Eric M; Ainslie, Kristy M

Batty, Cole J; Amouzougan, Eva A; A Carlock, Michael; Ross, Ted M; Bachelder, Eric M; Ainslie, Kristy M.

Afiliação

Batty CJ; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Amouzougan EA; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
A Carlock M; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA.
Ross TM; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA; Department of Infectious Diseases, University of Georgia, Athens, GA, USA.
Bachelder EM; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ainslie KM; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Joint Department of B

Int J Pharm ; 630: 122429, 2023 Jan 05.

Article em En | MEDLINE | ID: mdl-36436743

Assuntos

Vacinas contra Influenza; Influenza Humana; Infecções por Orthomyxoviridae; Camundongos; Animais; Humanos; Influenza Humana/prevenção & controle; Hemaglutininas; Dextranos/química; Preparações de Ação Retardada; Anticorpos Antivirais; Adjuvantes Imunológicos; Antígenos; Oligodesoxirribonucleotídeos; Glicoproteínas de Hemaglutininação de Vírus da Influenza/química; Infecções por Orthomyxoviridae/prevenção & controle

Palavras-chave

Intramuscular injection; Nanoparticle vaccine; Seasonal influenza vaccine; Tunable degradation; Universal influenza vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Infecções por Orthomyxoviridae / Influenza Humana Limite: Animals / Humans Idioma: En Revista: Int J Pharm Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda

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