AMPK activator decelerates osteoarthritis development by inhibition of ß-catenin signaling in chondrocytes.

Zhu, Zhenglin; Huang, Yanran; Li, Jun; Yi, Dan; Liao, Junyi; Xiao, Jun; Xiao, Guozhi; Tong, Liping; Huang, Wei; Di, Chen

Zhu, Zhenglin; Huang, Yanran; Li, Jun; Yi, Dan; Liao, Junyi; Xiao, Jun; Xiao, Guozhi; Tong, Liping; Huang, Wei; Di, Chen.

Afiliação

Zhu Z; Research Center for Computer-Aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Huang Y; Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Li J; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yi D; Research Center for Computer-Aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Liao J; Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Xiao J; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xiao G; Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA.
Tong L; Research Center for Computer-Aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Huang W; Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Di C; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

J Orthop Translat ; 38: 158-166, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36439631

Palavras-chave

AMPK; Chondrocyte; Metformin; Osteoarthritis; Osteoarthritis, OA; Phosphorylation; ß-catenin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Orthop Translat Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Singapura

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