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Mu Opioid Receptor Dynamics in Healthy Volunteers with a History of Childhood Maltreatment.
Hill, Kathryn R; Hsu, David T; Taylor, Stephan F; Ogden, R Todd; Parsey, Ramin V; DeLorenzo, Christine.
Afiliação
  • Hill KR; Department of Psychiatry, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794 United States.
  • Hsu DT; Department of Psychiatry, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794 United States.
  • Taylor SF; Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109 USA.
  • Ogden RT; Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109 USA.
  • Parsey RV; Department of Biostatistics, Columbia University Mailman School of Public Health, NY, NY 10032 USA.
  • DeLorenzo C; Department of Psychiatry, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794 United States.
J Child Adolesc Trauma ; 15(4): 1105-1112, 2022 Dec.
Article em En | MEDLINE | ID: mdl-36439668
Evidence suggests that adults with a history of childhood maltreatment, the experience of emotional or physical neglect and/or abuse within the family during childhood, have blunted reward and stress processing, and higher risk of depression. The mu opioid receptor rich nucleus accumbens and amygdala are critical to reward and stress processing respectively. We hypothesized that nucleus accumbens and amygdala mu opioid receptor densities and activity (change in receptor binding due to endogenous opioid release or receptor conformation change) were negatively associated with childhood maltreatment in healthy young adults. Maltreatment was assessed with the Childhood Trauma Questionnaire (CTQ). Healthy participants, n = 75 (52% female) completed [11C]carfentanil positron emission tomography imaging labeling mu opioid receptors. The relationship between CTQ score and binding potential (BPND, proportional to density of unoccupied receptors) was evaluated with a linear mixed effects model. No significant relationship was found between CTQ score and BPND (f = 3.28; df = 1, 73; p = 0.074) or change in BPND (activity) (t = 1.48; df = 198.3; p = 0.14). This is the first investigation of mu opioid receptors in those with childhood maltreatment. We did not identify a significant relationship between mu opioid receptor dynamics and severity of maltreatment in those without psychopathology. Because this cohort has a low CTQ score average, this may indicate that those with low severity of maltreatment may not have associated changes in mu opioid receptor dynamics. Future directions include evaluating a cohort with increased severity of childhood maltreatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Child Adolesc Trauma Ano de publicação: 2022 Tipo de documento: Article País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Child Adolesc Trauma Ano de publicação: 2022 Tipo de documento: Article País de publicação: Suíça