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Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.
Costantino, Luca; Ferrari, Stefania; Santucci, Matteo; Salo-Ahen, Outi M H; Carosati, Emanuele; Franchini, Silvia; Lauriola, Angela; Pozzi, Cecilia; Trande, Matteo; Gozzi, Gaia; Saxena, Puneet; Cannazza, Giuseppe; Losi, Lorena; Cardinale, Daniela; Venturelli, Alberto; Quotadamo, Antonio; Linciano, Pasquale; Tagliazucchi, Lorenzo; Moschella, Maria Gaetana; Guerrini, Remo; Pacifico, Salvatore; Luciani, Rosaria; Genovese, Filippo; Henrich, Stefan; Alboni, Silvia; Santarem, Nuno; da Silva Cordeiro, Anabela; Giovannetti, Elisa; Peters, Godefridus J; Pinton, Paolo; Rimessi, Alessandro; Cruciani, Gabriele; Stroud, Robert M; Wade, Rebecca C; Mangani, Stefano; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola.
Afiliação
  • Costantino L; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Ferrari S; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Santucci M; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Salo-Ahen OMH; Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
  • Carosati E; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
  • Franchini S; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Lauriola A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Pozzi C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
  • Trande M; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Gozzi G; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Saxena P; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Cannazza G; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Losi L; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Cardinale D; Respiratory, Critical Care & Anesthesia UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
  • Venturelli A; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Quotadamo A; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Linciano P; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Tagliazucchi L; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Moschella MG; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Guerrini R; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy, Modena, Italy.
  • Pacifico S; Department of Chemical and Pharmaceutical Science, University of Ferrara, Ferrara, Italy.
  • Luciani R; Department of Chemical and Pharmaceutical Science, University of Ferrara, Ferrara, Italy.
  • Genovese F; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Henrich S; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Alboni S; Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
  • Santarem N; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • da Silva Cordeiro A; IBMC I3S, Porto, Portugal.
  • Giovannetti E; IBMC I3S, Porto, Portugal.
  • Peters GJ; Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
  • Pinton P; Department of Medical Oncology, Amsterdam University Medical Center, Cancer Center Amsterdam, 1081HV, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
  • Rimessi A; CancerPharmacology Lab, Fondazione Pisana per la Scienza, Pisa, Italy.
  • Cruciani G; Department of Medical Oncology, Amsterdam University Medical Center, Cancer Center Amsterdam, 1081HV, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
  • Stroud RM; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
  • Wade RC; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
  • Mangani S; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
  • Marverti G; Biochemistry and Biophysics Department, University of California San Francisco, San Francisco, United States.
  • D'Arca D; Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
  • Ponterini G; Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany.
  • Costi MP; Center for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany.
Elife ; 112022 12 07.
Article em En | MEDLINE | ID: mdl-36475542
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Timidilato Sintase Limite: Animals / Female / Humans Idioma: En Revista: Elife Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Timidilato Sintase Limite: Animals / Female / Humans Idioma: En Revista: Elife Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália País de publicação: Reino Unido