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Role of supplementary motor area in cervical dystonia and sensory tricks.
Cho, Hyun Joo; Waugh, Rebecca; Wu, Tianxia; Panyakaew, Pattamon; Mente, Karin; Urbano, Demelio; Hallett, Mark; Horovitz, Silvina G.
Afiliação
  • Cho HJ; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. hyunjoo.cho@nih.gov.
  • Waugh R; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Wu T; Department of Psychology, University of Virginia, Charlottesville, VA, USA.
  • Panyakaew P; Clinical Trial Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Mente K; Department of Medicine, Chulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Faculty of Medicine, Chulalongkorn University and King, Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
  • Urbano D; Departments of Neurology and Pathology, Case Western Reserve University, Cleveland, USA.
  • Hallett M; Neurology Service, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
  • Horovitz SG; Cleveland Alzheimer's Disease Research Center, Cleveland, OH, USA.
Sci Rep ; 12(1): 21206, 2022 12 08.
Article em En | MEDLINE | ID: mdl-36481868
Sensory trick is a characteristic feature of cervical dystonia (CD), where a light touch on the area adjacent to the dystonia temporarily improves symptoms. Clinical benefit from sensory tricks can be observed before tactile contact is made or even by imagination. The supplementary motor area (SMA) may dynamically interact with the sensorimotor network and other brain regions during sensory tricks in patients with CD. In this study, we examined the functional connectivity of the SMA at rest and during sensory trick performance and imagination in CD patients compared to healthy controls using functional magnetic resonance imaging. The functional connectivity between the SMA and left intraparietal sulcus (IPS) region was lower in CD patients at rest and it increased with sensory trick imagination and performance. SMA-right cerebellum connectivity also increased with sensory trick imagination in CD patients, while it decreased in healthy controls. In CD patients, SMA connectivity increased in the brain regions involved in sensorimotor integration during sensory trick performance and imagination. Our study results showed a crucial role of SMA in sensorimotor processing during sensory trick performance and imagination and suggest the IPS as a novel potential therapeutic target for brain modulation.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Torcicolo / Córtex Motor Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Torcicolo / Córtex Motor Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido