Determination of pioglitazone hydrochloride by flow injection chemiluminescence tris(2,2'-bipyridyl)ruthenium(II)-silver(III) complex system.
Luminescence
; 38(2): 99-108, 2023 Feb.
Article
em En
| MEDLINE
| ID: mdl-36494159
ABSTRACT
A novel flow injection-chemiluminescence (FI-CL) approach is proposed for the assay of pioglitazone hydrochloride (PG-HCl) based on its enhancing influence on the tris(2,2'-bipyridyl)ruthenium(II)-silver(III) complex (Ru(bipy)3 2+ -DPA) CL system in sulfuric acid medium. The possible CL reaction mechanism is discussed with CL and ultraviolet (UV) spectra. The optimum experimental conditions were found as Ru(bipy)3 2+ , 5.0 × 10-5 M; sulfuric acid, 1.0 × 10-3 M; diperiodatoargentate(III) (DPA), 1.0 × 10-4 M; potassium hydroxide, 1.0 × 10-3 M; flow rate 4.0 ml min-1 for each flow stream and sample loop volume, 180 µl. The CL intensity of PG-HCl was linear in the range of 1.0 × 10-3 to 5.0 mg L-1 (R2 = 0.9998, n = 10) with limit of detection [LOD, signal-to-noise ratio (S/N) = 3] of 2.2 × 10-4 mg L-1 , limit of quantification (LOQ, S/N = 10) of 6.7 × 10-4 mg L-1 , relative standard deviation (RSD) of 1.0 to 3.3% and sampling rate of 106 h-1 . The methodology was satisfactorily used to quantify PG-HCl in pharmaceutical tablets with recoveries ranging from 93.17 to 102.77 and RSD from 1.9 to 2.8%.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rutênio
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Prata
Idioma:
En
Revista:
Luminescence
Assunto da revista:
BIOFISICA
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BIOQUIMICA
Ano de publicação:
2023
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Article
País de afiliação:
Paquistão