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The Biosynthesized Zinc Oxide Nanoparticles' Antiviral Activity in Combination with Pelargonium zonale Extract against the Human Corona 229E Virus.
Alqahtani, Abdulsalam A; El Raey, Mohamed A; Abdelsalam, Eman; Ibrahim, Ammar M; Alqahtani, Omaish; Torky, Zenab Aly; Attia, Hany G.
Afiliação
  • Alqahtani AA; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 1988, Saudi Arabia.
  • El Raey MA; Department of Phytochemistry and Plant Systematics, National Research Centre, Dokki, Cairo 12622, Egypt.
  • Abdelsalam E; Department of Chemistry of Microbial and Natural Products, National Research Centre, Dokki, Cairo 12622, Egypt.
  • Ibrahim AM; Applied Medical Sciences College, Najran University, Najran 1988, Saudi Arabia.
  • Alqahtani O; Department of Pharmacognosy, College of Pharmacy, Najran University, Najran 1988, Saudi Arabia.
  • Torky ZA; Department of Microbiology, Faculty of Science, Ain Shams University, Cairo 11241, Egypt.
  • Attia HG; Department of Pharmacognosy, College of Pharmacy, Najran University, Najran 1988, Saudi Arabia.
Molecules ; 27(23)2022 Nov 30.
Article em En | MEDLINE | ID: mdl-36500468
Almost one-third of all infectious diseases are caused by viruses, and these diseases account for nearly 20% of all deaths globally. It is becoming increasingly clear that highly contagious viral infections pose a significant threat to global health and economy around the world. The need for innovative, affordable, and safe antiviral therapies is a must. Zinc oxide nanoparticles are novel materials of low toxicity and low cost and are known for their antiviral activity. The genus Pelargonium was previously reported for its antiviral and antimicrobial activity. In this work, Pelargonium zonale leaf extract chemical profile was studied via high-performance liquid chromatography (HPLC) and was used for the biosynthesis of zinc oxide nanoparticles. Furthermore, the antiviral activity of the combination of P. zonale extract and the biosynthesized nanoparticles of ZnO against the human corona 229E virus was investigated. Results revealed that ZnONPs had been biosynthesized with an average particle size of about 5.5 nm and characterized with UV, FTIR, TEM, XRD, and SEM. The antiviral activity showed significant activity and differences among the tested samples in favor of the combination of P. zonale extract and ZnONPs (ZnONPs/Ex). The lowest IC50, 2.028 µg/mL, and the highest SI, 68.4 of ZnONPs/Ex, assert the highest antiviral activity of the combination against human coronavirus (229E).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / Óxido de Zinco / Pelargonium / Nanopartículas / Nanopartículas Metálicas Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / Óxido de Zinco / Pelargonium / Nanopartículas / Nanopartículas Metálicas Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita País de publicação: Suíça