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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Chavarria-Smith, Joseph; Chiu, Cecilia P C; Jackman, Janet K; Yin, Jianping; Zhang, Juan; Hackney, Jason A; Lin, Wei-Yu; Tyagi, Tulika; Sun, Yonglian; Tao, Janet; Dunlap, Debra; Morton, William D; Ghodge, Swapnil V; Maun, Henry R; Li, Hong; Hernandez-Barry, Hilda; Loyet, Kelly M; Chen, Emily; Liu, John; Tam, Christine; Yaspan, Brian L; Cai, Hao; Balazs, Mercedesz; Arron, Joseph R; Li, Jing; Wittwer, Arthur J; Pappu, Rajita; Austin, Cary D; Lee, Wyne P; Lazarus, Robert A; Sudhamsu, Jawahar; Koerber, James T; Yi, Tangsheng.
Afiliação
  • Chavarria-Smith J; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chiu CPC; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jackman JK; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Yin J; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zhang J; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Hackney JA; Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lin WY; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Tyagi T; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Sun Y; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Tao J; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Dunlap D; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Morton WD; Confluence Discovery Technologies Inc., 4320 Duncan Ave, Suite 400, St. Louis, MO 63108, USA.
  • Ghodge SV; Departments of Biological Chemistry and Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Maun HR; Departments of Biological Chemistry and Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Li H; Department of Protein Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Hernandez-Barry H; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Loyet KM; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chen E; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Liu J; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Tam C; Department of Biomolecular Resources, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Yaspan BL; Department of Human Genetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Cai H; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Balazs M; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Arron JR; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Li J; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wittwer AJ; Confluence Discovery Technologies Inc., 4320 Duncan Ave, Suite 400, St. Louis, MO 63108, USA.
  • Pappu R; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Austin CD; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lee WP; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lazarus RA; Departments of Biological Chemistry and Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Sudhamsu J; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Koerber JT; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Yi T; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sci Transl Med ; 14(675): eabp9159, 2022 12 14.
Article em En | MEDLINE | ID: mdl-36516271
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dermatopatias / Dermatite Atópica / Síndrome de Netherton Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dermatopatias / Dermatite Atópica / Síndrome de Netherton Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos