The R736H cancer mutation in DNMT3A modulates the properties of the FF-subunit interface.

Kunert, Stefan; Emperle, Max; Adam, Sabrina; Bräcker, Julia; Brockmeyer, Jens; Rajavelu, Arumugam; Jeltsch, Albert

Kunert, Stefan; Emperle, Max; Adam, Sabrina; Bräcker, Julia; Brockmeyer, Jens; Rajavelu, Arumugam; Jeltsch, Albert.

Afiliação

Kunert S; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569, Stuttgart, Germany.
Emperle M; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569, Stuttgart, Germany.
Adam S; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569, Stuttgart, Germany.
Bräcker J; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569, Stuttgart, Germany.
Brockmeyer J; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569, Stuttgart, Germany.
Rajavelu A; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569, Stuttgart, Germany.
Jeltsch A; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569, Stuttgart, Germany. Electronic address: albert.jeltsch@ibtb.uni-stuttgart.de.

Biochimie ; 208: 66-74, 2023 May.

Article em En | MEDLINE | ID: mdl-36528185

Assuntos

Neoplasias; Humanos; Neoplasias/genética; Fatores de Transcrição; Heterozigoto; Mutação; DNA

Palavras-chave

AML; DNA methylation; DNMT3A; Enzyme mechanism; Somatic cancer mutation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Limite: Humans Idioma: En Revista: Biochimie Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha País de publicação: França

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