Antibody-Based In Vivo Imaging of Central Nervous System Targets-Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines.

Bredack, Christoph; Edelmann, Martin R; Borroni, Edilio; Gobbi, Luca C; Honer, Michael

Bredack, Christoph; Edelmann, Martin R; Borroni, Edilio; Gobbi, Luca C; Honer, Michael.

Afiliação

Bredack C; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Neuroscience and Rare Diseases, Biomarkers and Translational Technologies, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
Edelmann MR; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Therapeutic Modalities, Small Molecule Research, Isotope Synthesis, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
Borroni E; Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
Gobbi LC; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Neuroscience and Rare Diseases, Biomarkers and Translational Technologies, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
Honer M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Therapeutic Modalities, Small Molecule Research, Medicinal Chemistry, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.

Pharmaceuticals (Basel) ; 15(12)2022 Nov 22.

Article em En | MEDLINE | ID: mdl-36558900

Palavras-chave

CNS; PET; antibody; click chemistry; pretargeting; tetrazine; trans-cyclooctene; tritium

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suíça

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