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Sanwei sandalwood decoction ameliorates acute ischemiareperfusion injury in rats by modulating myocyte electrophysiological characteristics.
Wan, Quan; Wang, Yu; Yong, Ming; Hu, PengFei; Le Liang, Che Ge; Yang, Xiang Jun; Zhao, Xiao; San, Dan; Bai, Ting Ting; Tong, La Ga; Zhai, Jingbo; Zhao, Ming; Zhang, QingShan.
Afiliação
  • Wan Q; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Wang Y; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Yong M; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Hu P; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Le Liang CG; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Yang XJ; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Zhao X; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • San D; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Bai TT; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Tong G; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University.
  • Zhai J; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Tongliao 028000, PR China.
  • Zhao M; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University. Electronic addr
  • Zhang Q; Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, PR China; Inner Mongolia Minzu University, Tongliao, Inner Mongolia, P.R. China; Institute of Cardiovascular Diseases of Combination of Mongolian and Western Medicine of Inner Mongolia Minzu University. Electronic addr
Biomed Pharmacother ; 158: 114103, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36563556
ABSTRACT
Sanwei sandalwood decoction (SWTX) is a classical Chinese medicine formula and clinically effective treatment for coronary heart disease, including myocardial ischemia/reperfusion (I/R) injury. Because the treatment mechanism of SWTX in I/R injury remains obscure, we intended to analyze the potential cardioprotective effects of SWTX in rats with myocardial I/R injury. Our research revealed that SWTX prolonged ventricular conduction time in a dose-dependent manner. While SWTX significantly delayed left ventricular signal conduction velocity, it had no effect on left atrial conduction velocity. Under sinus conditions, low SWTX concentrations reduced left ventricular conduction dispersion, while high concentrations increased conduction dispersion. SWTX also prolonged the QRS interval, APD30/50/90, and ERP. In whole-cell patch clamp experiments on myocytes, Ito and Ikr were inhibited by SWTX. While SWTX had no effect on INa, the activation curve for Nav1.5 was left-shifted. Finally, SWTX reduced the probability of ventricular fibrillation and suppressed early and late depolarization in an acute I/R injury rat model. These findings shed light on the mechanism by which SWTX alleviates myocardial I/R injury.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / Santalum Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / Santalum Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article