An AI-assisted tool for efficient prostate cancer diagnosis in low-grade and low-volume cases.
Patterns (N Y)
; 3(12): 100642, 2022 Dec 09.
Article
em En
| MEDLINE
| ID: mdl-36569545
ABSTRACT
Pathologists diagnose prostate cancer by core needle biopsy. In low-grade and low-volume cases, they look for a few malignant glands out of hundreds within a core. They may miss a few malignant glands, resulting in repeat biopsies or missed therapeutic opportunities. This study developed a multi-resolution deep-learning pipeline to assist pathologists in detecting malignant glands in core needle biopsies of low-grade and low-volume cases. Analyzing a gland at multiple resolutions, our model exploited morphology and neighborhood information, which were crucial in prostate gland classification. We developed and tested our pipeline on the slides of a local cohort of 99 patients in Singapore. Besides, we made the images publicly available, becoming the first digital histopathology dataset of patients of Asian ancestry with prostatic carcinoma. Our multi-resolution classification model achieved an area under the receiver operating characteristic curve (AUROC) value of 0.992 (95% confidence interval [CI] 0.985-0.997) in the external validation study, showing the generalizability of our multi-resolution approach.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Patterns (N Y)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Singapura