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Combined nasal- and oropharyngeal self-swab provides equivalent performance compared to professionally collected oropharyngeal swabs in detecting SARS-CoV-2 in a real-life setting.
Hørlyck, Sofie; Nielsen, Sofie Holdflod; Gress, Tobias; Schneider, Uffe; Martel, Cyril Jean-Marie; Steenhard, Nina; Gredal, Niels Tobias; Mortensen, Shila; Cohen, Arieh S.
Afiliação
  • Hørlyck S; Test Center Denmark, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark.
  • Nielsen SH; Test Center Denmark, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark.
  • Gress T; Test Center Denmark, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark.
  • Schneider U; Department of Virus & Microbiological Special Diagnostics, Statens Serum Insititut, Artillerivej 5, 2300 Copenhagen, Denmark.
  • Martel CJ; Test Center Denmark, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark.
  • Steenhard N; Test Center Denmark, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark.
  • Gredal NT; Test Center Denmark Valby, Værkstedvej 56, 2500 Copenhagen, Denmark.
  • Mortensen S; Department of Virus & Microbiological Special Diagnostics, Statens Serum Insititut, Artillerivej 5, 2300 Copenhagen, Denmark.
  • Cohen AS; Test Center Denmark, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark. Electronic address: ACO@ssi.dk.
J Virol Methods ; 313: 114667, 2023 03.
Article em En | MEDLINE | ID: mdl-36572155
PURPOSE: To investigate the performance of a combined nasal midturbinate- and oropharyngeal (NAOP) self-swab compared to a deep oropharyngeal (OP) swab by health care workers (HCW) in detecting SARS-CoV-2 in a real-life setting. METHODS: Paired swabs from 1119 participants were included. RT-PCR were used to detect SARS-CoV-2 in both swab samples. RESULTS: 330 participants tested positive. The sensitivity of the combined self-swab and OP swab was 96.9 % and 95.4 % respectively, whereas the Ct-values for self-swabs were significantly lower compared to OP swabs. CONCLUSION: The combined NAOP self-swab outperformed the OP swab and thus, the NAOP self-swab may be an alternative sampling method under the given circumstances.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Humans Idioma: En Revista: J Virol Methods Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Humans Idioma: En Revista: J Virol Methods Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Holanda