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PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases.
Zhao, Xiangli; Lin, Yi; Liou, Benjamin; Fu, Wenyu; Jian, Jinlong; Fannie, Venette; Zhang, Wujuan; Setchell, Kenneth D R; Grabowski, Gregory A; Sun, Ying; Liu, Chuan-Ju.
Afiliação
  • Zhao X; Department of Orthopaedic Surgery, New York University Grossman School of Medicine, New York, NY 10003.
  • Lin Y; The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
  • Liou B; The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
  • Fu W; Department of Orthopaedic Surgery, New York University Grossman School of Medicine, New York, NY 10003.
  • Jian J; Department of Orthopaedic Surgery, New York University Grossman School of Medicine, New York, NY 10003.
  • Fannie V; The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
  • Zhang W; The Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
  • Setchell KDR; The Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
  • Grabowski GA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
  • Sun Y; The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
  • Liu CJ; The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Proc Natl Acad Sci U S A ; 120(1): e2210442120, 2023 01 03.
Article em En | MEDLINE | ID: mdl-36574647
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Progranulinas / Doença de Gaucher Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Progranulinas / Doença de Gaucher Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos