Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-&#954;B and RhoA/ROCK1/MLCP signaling.

Liu, Di; Xu, Wen; Tang, Yuan; Cao, Jingxue; Chen, Ran; Wu, Dingwei; Chen, Hongpeng; Su, Bo; Xu, Jinfu

Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling.

Liu, Di; Xu, Wen; Tang, Yuan; Cao, Jingxue; Chen, Ran; Wu, Dingwei; Chen, Hongpeng; Su, Bo; Xu, Jinfu.

Afiliação

Liu D; Central Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Xu W; Department of Radiation Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Tang Y; Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Cao J; Central Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Chen R; Basic Medical College, Bengbu Medical College, Bengbu, People's Republic of China.
Wu D; Central Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Chen H; Department of Radiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Su B; Central Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Xu J; Zhejiang Xianju Pharmaceutical Co., Ltd, Xianju, People's Republic of China.

Respir Res ; 23(1): 380, 2022 Dec 28.

Article em En | MEDLINE | ID: mdl-36575527

Assuntos

Obstrução das Vias Respiratórias; Doença Pulmonar Obstrutiva Crônica; Ratos; Camundongos; Animais; NF-kappa B/metabolismo; Ácido Risedrônico/uso terapêutico; Pulmão/metabolismo; Inflamação/metabolismo; Prenilação; Quinases Associadas a rho/metabolismo

Palavras-chave

Animal models; Chronic obstructive; Inflammation; Pulmonary disease; Risedronic acid

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Pulmonar Obstrutiva Crônica / Obstrução das Vias Respiratórias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Respir Res Ano de publicação: 2022 Tipo de documento: Article País de publicação: Reino Unido

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google