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A Pure Shift-Based Nuclear Magnetic Resonance Method for In-Phase Three-Dimensional Diffusion-Ordered Spectroscopy.
Zhan, Haolin; Hao, Mengyou; Lin, Enping; Zheng, Zeyu; Huang, Chengda; Cai, Shuhui; Cao, Shuohui; Huang, Yuqing; Chen, Zhong.
Afiliação
  • Zhan H; Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
  • Hao M; Department of Biomedical Engineering, Anhui Provincial Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Optoelectronics Engineering, Hefei University of Technology, Hefei, 230009, China.
  • Lin E; Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
  • Zheng Z; Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
  • Huang C; Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
  • Cai S; Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
  • Cao S; Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
  • Huang Y; Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
  • Chen Z; Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
Anal Chem ; 95(2): 1002-1007, 2023 01 17.
Article em En | MEDLINE | ID: mdl-36579454
Diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY) plays a vital role in mixture studies. However, its applications to complex mixture samples are generally limited by spectral congestion along the chemical shift domain caused by extensive J coupling networks and abundant compounds. Herein, we develop the in-phase multidimensional DOSY strategy for complex mixture analyses by simultaneously revealing molecular self-diffusion behaviors and multiplet structures with optimal spectral resolution. As a proof of concept, two pure shift-based three-dimensional (3D) DOSY protocols are proposed to record high-resolution 3D spectroscopic view with separated mixture components and their resolved multiplet coupling structures, thus suitable for analyzing complex mixtures that contain abundant compounds and complicated molecular structures, even under adverse magnetic field conditions. Therefore, this study shows a promising tool for component analyses and multiplet structure studies on practical mixture samples.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Misturas Complexas Tipo de estudo: Guideline Idioma: En Revista: Anal Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Misturas Complexas Tipo de estudo: Guideline Idioma: En Revista: Anal Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos