A Pure Shift-Based Nuclear Magnetic Resonance Method for In-Phase Three-Dimensional Diffusion-Ordered Spectroscopy.
Anal Chem
; 95(2): 1002-1007, 2023 01 17.
Article
em En
| MEDLINE
| ID: mdl-36579454
Diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY) plays a vital role in mixture studies. However, its applications to complex mixture samples are generally limited by spectral congestion along the chemical shift domain caused by extensive J coupling networks and abundant compounds. Herein, we develop the in-phase multidimensional DOSY strategy for complex mixture analyses by simultaneously revealing molecular self-diffusion behaviors and multiplet structures with optimal spectral resolution. As a proof of concept, two pure shift-based three-dimensional (3D) DOSY protocols are proposed to record high-resolution 3D spectroscopic view with separated mixture components and their resolved multiplet coupling structures, thus suitable for analyzing complex mixtures that contain abundant compounds and complicated molecular structures, even under adverse magnetic field conditions. Therefore, this study shows a promising tool for component analyses and multiplet structure studies on practical mixture samples.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Misturas Complexas
Tipo de estudo:
Guideline
Idioma:
En
Revista:
Anal Chem
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Estados Unidos