Decreased incidence of Duchenne muscular dystrophy in western Japan 1956-1980.
Neuroepidemiology
; 6(3): 130-8, 1987.
Article
em En
| MEDLINE
| ID: mdl-3658082
ABSTRACT
In 50 patients from 41 families of Duchenne muscular dystrophy (DMD) born between 1956 and 1980 in the San-in area of Japan, the changes in DMD incidence rate were analyzed through five periods of time 1956-1960, 1961-1965, 1966-1970, 1971-1975 and 1976-1980. The overall incidence decreased from 22.31 X 10(-5) live male births in the first period to 14.51 X 10(-5) in the last. This decrease was mainly related to the group of mothers who were definite carriers (p less than 0.005), and was probably due to genetic counselling of definite carrier families. For a further decrease in the incidence of DMD, the newborn male screening system for creatine phosphokinase (CPK) and appropriate genetic counselling might be effective. From an analysis of 28 families without previous family history, the expected proportion of maternal carriers was 0.57.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Distrofias Musculares
Tipo de estudo:
Incidence_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Neuroepidemiology
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Japão