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Transposable elements and Alzheimer's disease pathogenesis.
Evering, Teresa H; Marston, Jez L; Gan, Li; Nixon, Douglas F.
Afiliação
  • Evering TH; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Marston JL; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Gan L; Helen and Robert Appel Alzheimer's Disease Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Nixon DF; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA. Electronic address: dnixon@med.cornell.edu.
Trends Neurosci ; 46(3): 170-172, 2023 03.
Article em En | MEDLINE | ID: mdl-36588011
ABSTRACT
Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid ß (Aß) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Trends Neurosci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Trends Neurosci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos