Transposable elements and Alzheimer's disease pathogenesis.
Trends Neurosci
; 46(3): 170-172, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36588011
ABSTRACT
Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid ß (Aß) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Trends Neurosci
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos