The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis <i>via</i> targeting CHOP and BAK which is augmented by cisplatin.

Kuang, Yeye; He, Zhanglian; Li, Lili; Wang, Chan; Cheng, Xiaoqing; Shi, Qinglan; Fu, Guoxiang; Ying, Jianming; Tao, Qian; Hu, Xiaotong

The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis via targeting CHOP and BAK which is augmented by cisplatin.

Kuang, Yeye; He, Zhanglian; Li, Lili; Wang, Chan; Cheng, Xiaoqing; Shi, Qinglan; Fu, Guoxiang; Ying, Jianming; Tao, Qian; Hu, Xiaotong.

Afiliação

Kuang Y; Biomedical Research Center, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
He Z; Department of Pathology, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Li L; Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou 310016, Zhejiang, China.
Wang C; Biomedical Research Center, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Cheng X; Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou 310016, Zhejiang, China.
Shi Q; Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
Fu G; Biomedical Research Center, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Ying J; Department of Pathology, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Tao Q; Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou 310016, Zhejiang, China.
Hu X; Department of Pathology, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.

Int J Biol Sci ; 19(1): 120-136, 2023.

Article em En | MEDLINE | ID: mdl-36594085

Assuntos

Cisplatino; Neoplasias Gástricas; Humanos; Cisplatino/farmacologia; Cisplatino/uso terapêutico; Apoptose/genética; Neoplasias Gástricas/tratamento farmacológico; Neoplasias Gástricas/genética; Neoplasias Gástricas/metabolismo; Regulação da Expressão Gênica; Carcinogênese; Estresse do Retículo Endoplasmático/genética; Fator de Transcrição CHOP/genética; Fator de Transcrição CHOP/metabolismo; Linhagem Celular Tumoral

Palavras-chave

BAK.; CHOP; HAND1; apoptosis; gastric cancer; methylation; tumor suppressor gene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Cisplatino Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Biol Sci Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Austrália

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