The structural basis of conserved residue variant effect on enzyme activity of UGT2B15.

Zhang, Lin; Zhang, Xuerong; Yang, Yibing; Gu, Jiangyong; Liu, Zhongqiu; Wang, Caiyan

Zhang, Lin; Zhang, Xuerong; Yang, Yibing; Gu, Jiangyong; Liu, Zhongqiu; Wang, Caiyan.

Afiliação

Zhang L; Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 51
Zhang X; Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 51
Yang Y; Research Center of Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Gu J; Research Center of Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Liu Z; Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 51
Wang C; Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 51

Biochim Biophys Acta Proteins Proteom ; 1871(3): 140888, 2023 05 01.

Article em En | MEDLINE | ID: mdl-36610584

Assuntos

Glucuronosiltransferase; Uridina Difosfato Ácido Glucurônico; Glucuronosiltransferase/genética; Glucuronosiltransferase/química; Glucuronosiltransferase/metabolismo; Difração de Raios X; Cinética

Palavras-chave

Glucuronidation; Molecular dynamic simulation; Structure; UGT2B15 mutations

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Uridina Difosfato Ácido Glucurônico / Glucuronosiltransferase Idioma: En Revista: Biochim Biophys Acta Proteins Proteom Ano de publicação: 2023 Tipo de documento: Article País de publicação: Holanda

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