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Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants.
Rodriguez-Aponte, Sergio A; Dalvie, Neil C; Wong, Ting Y; Johnston, Ryan S; Naranjo, Christopher A; Bajoria, Sakshi; Kumru, Ozan S; Kaur, Kawaljit; Russ, Brynnan P; Lee, Katherine S; Cyphert, Holly A; Barbier, Mariette; Rao, Harish D; Rajurkar, Meghraj P; Lothe, Rakesh R; Shaligram, Umesh S; Batwal, Saurabh; Chandrasekaran, Rahul; Nagar, Gaurav; Kleanthous, Harry; Biswas, Sumi; Bevere, Justin R; Joshi, Sangeeta B; Volkin, David B; Damron, F Heath; Love, J Christopher.
Afiliação
  • Rodriguez-Aponte SA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Dalvie NC; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Wong TY; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506, USA; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.
  • Johnston RS; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Naranjo CA; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Bajoria S; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, KS 66047, USA.
  • Kumru OS; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, KS 66047, USA.
  • Kaur K; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, KS 66047, USA.
  • Russ BP; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506, USA; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.
  • Lee KS; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506, USA; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.
  • Cyphert HA; Department of Biological Sciences, Marshall University, Huntington, WV 26506, USA.
  • Barbier M; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506, USA; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.
  • Rao HD; Serum Institute of India Pvt. Ltd., Pune 411028, India.
  • Rajurkar MP; Serum Institute of India Pvt. Ltd., Pune 411028, India.
  • Lothe RR; Serum Institute of India Pvt. Ltd., Pune 411028, India.
  • Shaligram US; Serum Institute of India Pvt. Ltd., Pune 411028, India.
  • Batwal S; Serum Institute of India Pvt. Ltd., Pune 411028, India.
  • Chandrasekaran R; Serum Institute of India Pvt. Ltd., Pune 411028, India.
  • Nagar G; Serum Institute of India Pvt. Ltd., Pune 411028, India.
  • Kleanthous H; Bill & Melinda Gates Foundation, Seattle, WA 98109, USA.
  • Biswas S; SpyBiotech Limited, Oxford Business Park North, Oxford OX4 2JZ, UK.
  • Bevere JR; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506, USA; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.
  • Joshi SB; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, KS 66047, USA.
  • Volkin DB; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, KS 66047, USA.
  • Damron FH; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506, USA; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.
  • Love JC; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic add
Vaccine ; 41(5): 1108-1118, 2023 01 27.
Article em En | MEDLINE | ID: mdl-36610932
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Revista: Vaccine Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Revista: Vaccine Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda