Investigation of biomarkers in a rare case of fulminant necrotizing enterocolitis in a preterm infant.
Fukushima J Med Sci
; 69(1): 29-36, 2023 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-36631077
ABSTRACT
We encountered a very rare case of fulminant necrotizing enterocolitis (F-NEC) in a preterm male baby. The course of NEC and sepsis in this case was clearly different from the usual course. After onset at 14 days of life, catheter-related bloodstream infection was first assumed, and antibiotics and γ-globulin administration were started. However, 12 hours after onset, the baby's abdominal distension increased remarkably, and his entire abdominal wall turned red to purple. Escherichia coli were isolated from the blood culture, but the catheter tip culture was negative. Exchange transfusion was performed 32 hours after onset, but no significant changes were observed in the baby's general condition, and he died 46 hours after onset. The acute phase reactants of CRP and α1-acid glycoprotein increased, but haptoglobin did not. Although IL-1ß and TNFα increased as expected with sepsis, IL-6, IL-8, IL-10, and G-CSF however increased to a greater extent than expected. From the above, we diagnosed the development of intestinal necrosis as a result of widespread intestinal ischemia, and that sepsis was associated with this poor condition.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Enterocolite Necrosante
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
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Infant
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Male
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Newborn
Idioma:
En
Revista:
Fukushima J Med Sci
Ano de publicação:
2023
Tipo de documento:
Article