The effect of concanavalin A on the rat electro-olfactogram at various odorant concentrations.
Biochem J
; 245(1): 185-9, 1987 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-3663144
ABSTRACT
We have studied the effect of concanavalin A (Con A) on the rat electro-olfactogram response to several odorants. Each odorant was applied over a range of concentrations. For hydrophobic odorants whose response was affected by Con A, the diminution in response was maximal at odorant concentrations of about 1 microM in the olfactory mucus. The (odour) concentration-dependence of the change is compatible with the idea that Con A inactivates one or more types of olfactory receptor that normally bind odorants with dissociation constants of the order of 100 nM. With hydrophilic odorants we had to apply concentrations very much higher than this to elicit any response from the system. At these high concentrations we could observe Con A-induced diminutions in response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Olfato
/
Mucosa Olfatória
/
Concanavalina A
Limite:
Animals
Idioma:
En
Revista:
Biochem J
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Reino Unido