Mutational fitness landscape of human influenza H3N2 neuraminidase.

Lei, Ruipeng; Hernandez Garcia, Andrea; Tan, Timothy J C; Teo, Qi Wen; Wang, Yiquan; Zhang, Xiwen; Luo, Shitong; Nair, Satish K; Peng, Jian; Wu, Nicholas C

Lei, Ruipeng; Hernandez Garcia, Andrea; Tan, Timothy J C; Teo, Qi Wen; Wang, Yiquan; Zhang, Xiwen; Luo, Shitong; Nair, Satish K; Peng, Jian; Wu, Nicholas C.

Afiliação

Lei R; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Hernandez Garcia A; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Tan TJC; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Teo QW; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Wang Y; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Zhang X; HeliXon Limited, Beijing 100084, China.
Luo S; HeliXon Limited, Beijing 100084, China.
Nair SK; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, U
Peng J; HeliXon Limited, Beijing 100084, China; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: jianpeng@illinois.edu.
Wu NC; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, U

Cell Rep ; 42(1): 111951, 2023 01 31.

Article em En | MEDLINE | ID: mdl-36640354

Assuntos

Influenza Humana; Humanos; Influenza Humana/genética; Vírus da Influenza A Subtipo H3N2/genética; Neuraminidase/genética; Neuraminidase/metabolismo; Evolução Molecular; Mutação/genética

Palavras-chave

CP: Molecular biology; deep mutational scanning; evolution; influenza; neuraminidase; protein language model; protein stability; protein structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Influenza Humana Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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