Complexed Crystal Structure of the Dihydroorotase Domain of Human CAD Protein with the Anticancer Drug 5-Fluorouracil.

Lin, En-Shyh; Huang, Yen-Hua; Yang, Po-Chun; Peng, Wei-Feng; Huang, Cheng-Yang

Lin, En-Shyh; Huang, Yen-Hua; Yang, Po-Chun; Peng, Wei-Feng; Huang, Cheng-Yang.

Afiliação

Lin ES; Department of Beauty Science, National Taichung University of Science and Technology, Taichung City 403, Taiwan.
Huang YH; Department of Beauty Science, National Taichung University of Science and Technology, Taichung City 403, Taiwan.
Yang PC; Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan.
Peng WF; Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan.
Huang CY; Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan.

Biomolecules ; 13(1)2023 01 11.

Article em En | MEDLINE | ID: mdl-36671534

Assuntos

Antineoplásicos; Di-Hidro-Orotase; Animais; Humanos; Di-Hidro-Orotase/química; Di-Hidro-Orotase/metabolismo; Malatos; Ligantes; Fluoruracila/farmacologia; Antineoplásicos/farmacologia; Mamíferos/metabolismo

Palavras-chave

5-fluorouracil; CAD; anticancer drug; crystal structure; dihydroorotase; dihydropyrimidinase; dynamic loop; fluorescence quenching; pyrimidine biosynthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Di-Hidro-Orotase / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Biomolecules Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Suíça

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