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Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis.
Li, Jiaxin; Chen, Yuqi; Li, Rui; Zhang, Xianglong; Chen, Tao; Mei, Fengyi; Liu, Ruofan; Chen, Meiling; Ge, Yue; Hu, Hongbin; Wei, Rongjuan; Chen, Zhenfeng; Fan, Hongying; Zeng, Zhenhua; Deng, Yongqiang; Luo, Haihua; Hu, Shuiwang; Cai, Shumin; Wu, Feng; Shi, Nengxian; Wang, Zhang; Zeng, Yunong; Xie, Ming; Jiang, Yong; Chen, Zhongqing; Jia, Wei; Chen, Peng.
Afiliação
  • Li J; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Chen Y; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Li R; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Zhang X; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Chen T; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Mei F; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Liu R; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Chen M; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Ge Y; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Hu H; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Wei R; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Chen Z; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Fan H; Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
  • Zeng Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Deng Y; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Luo H; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Hu S; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Cai S; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Wu F; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Shi N; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Wang Z; Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou 510515, China.
  • Zeng Y; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Xie M; Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Jiang Y; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Chen Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: zhongqingchen2008@163.com.
  • Jia W; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, China. Electronic address: weijia1@h
  • Chen P; Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: perchen@s
Mol Ther ; 31(4): 1017-1032, 2023 04 05.
Article em En | MEDLINE | ID: mdl-36698311
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China