Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.

Bridges, Hannah R; Blaza, James N; Yin, Zhan; Chung, Injae; Pollak, Michael N; Hirst, Judy

Bridges, Hannah R; Blaza, James N; Yin, Zhan; Chung, Injae; Pollak, Michael N; Hirst, Judy.

Afiliação

Bridges HR; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Blaza JN; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Yin Z; Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, The University of York, York YO10 5DD, UK.
Chung I; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Pollak MN; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Hirst J; Lady Davis Institute of the Jewish General Hospital and Department of Oncology, McGill University, Montreal, QC H3T 1E2, Canada.

Science ; 379(6630): 351-357, 2023 01 27.

Article em En | MEDLINE | ID: mdl-36701435

Assuntos

Biguanidas; Complexo I de Transporte de Elétrons; Animais; Microscopia Crioeletrônica; Complexo I de Transporte de Elétrons/antagonistas & inibidores; Metformina/farmacologia; Mitocôndrias/metabolismo; Biguanidas/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biguanidas / Complexo I de Transporte de Elétrons Limite: Animals Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos

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