Coenzyme Q biochemistry and biosynthesis.
Trends Biochem Sci
; 48(5): 463-476, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36702698
ABSTRACT
Coenzyme Q (CoQ) is a remarkably hydrophobic, redox-active lipid that empowers diverse cellular processes. Although most known for shuttling electrons between mitochondrial electron transport chain (ETC) complexes, the roles for CoQ are far more wide-reaching and ever-expanding. CoQ serves as a conduit for electrons from myriad pathways to enter the ETC, acts as a cofactor for biosynthetic and catabolic reactions, detoxifies damaging lipid species, and engages in cellular signaling and oxygen sensing. Many open questions remain regarding the biosynthesis, transport, and metabolism of CoQ, which hinders our ability to treat human CoQ deficiency. Here, we recount progress in filling these knowledge gaps, highlight unanswered questions, and underscore the need for novel tools to enable discoveries and improve the treatment of CoQ-related diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ubiquinona
/
Doenças Mitocondriais
Limite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos