Intraindividual Change in Cognitive Function Among Adults With Systemic Lupus Erythematosus: A Markov Analysis Over 7 Years.
ACR Open Rheumatol
; 5(3): 124-131, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36705542
ABSTRACT
OBJECTIVE:
Cognitive impairment is prevalent in systemic lupus erythematosus (SLE). There remain gaps in understanding cognition and SLE longitudinally. We studied intraindividual change in cognition in SLE over time.METHODS:
Data were from the University of California, San Francisco Lupus Outcome Study, which included 1281 adults with SLE. The Hopkins Verbal Learning Test-Revised (HVLT-R) and the Controlled Oral Word Association Test (COWAT) were administered annually over 7 years. A two-state Markov analysis was used to model transition intensities for probabilities of change in cognition. Logistic regression examined the association between clinical variables and cognitive change.RESULTS:
Minimal transition between cognitive states was observed in the Markov analysis. Using the COWAT, higher levels of self-reported depression were associated with decreased likelihood of cognitive improvement (Relative Risk [RR] 0.98; 95% confidence interval [CI] 0.96-0.99), and higher self-reported disease severity was associated with cognitive decline (RR 1.05; 95% CI 1.02-1.09). Using the HVLT-R, increasing age (RR 1.02; 95% CI 1.01-1.03) and higher education level (RR 1.82; 95% CI 1.28-2.58) were associated with cognitive improvement, and higher self-reported disease severity (RR 1.02; 95% CI 1.01-1.03) and depression (RR 1.05; 95% CI 1.03-1.07) were associated with cognitive decline.CONCLUSION:
Most individuals with SLE did not transition between states of high (Z score ≥ -1.5) or low (Z score < -1.5) cognition in a Markov analysis over a 7-year assessment period, highlighting a degree of relative stability in cognition over time. Increasing age and higher education levels were associated with greater likelihood of cognitive improvement. Greater self-reported SLE disease severity and depression were associated with cognitive decline.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
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Health_economic_evaluation
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Prognostic_studies
Idioma:
En
Revista:
ACR Open Rheumatol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Canadá
País de publicação:
EEUU
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ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA