The role of complement C3 in the outcome of regional myocardial infarction.
Biochem Biophys Rep
; 33: 101434, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36748063
ABSTRACT
Coronary heart disease leading to myocardial ischemia is a major cause of heart failure. A hallmark of heart failure is myocardial fibrosis. Using a murine model of myocardial ischemia/reperfusion injury (IRI), we showed that, following IRI, in mice genetically deficient in the central factor of complement system, C3, myocardial necrosis was reduced compared with WT mice. Four weeks after the ischemic period, the C3-/- mice had significantly less cardiac fibrosis and better cardiac function than the WT controls. Overall, our results suggest that innate immune response through complement C3 plays an important role in necrotic cell death, which contributes to the cardiac fibrosis that underlies post-infarction heart failure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Biochem Biophys Rep
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos