New cembranoids from the leaves and twigs of <i>Croton yanhuii</i> Y. T. Chang.

Zhang, Daidi; Wang, Didi; Li, Zhenwei; Guo, Dean; Li, Wei

New cembranoids from the leaves and twigs of Croton yanhuii Y. T. Chang.

Zhang, Daidi; Wang, Didi; Li, Zhenwei; Guo, Dean; Li, Wei.

Afiliação

Zhang D; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Wang D; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Li Z; School of Pharmacy, Guizhou Medical University, Guiyang, China.
Guo D; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Li W; Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Nat Prod Res ; : 1-7, 2023 Feb 10.

Article em En | MEDLINE | ID: mdl-36762720

ABSTRACT

ABSTRACT

Crotonyanes A (1) and B (2), two new cembranoids were isolated from the leaves and twigs of Croton yanhuii Y. T. Chang. Their structures were elucidated by extensive spectroscopic analyses and quantum chemical calculations. Bioassays verified that compound 1 exhibited an inhibitory effect on nitric oxide (NO) production in RAW 264.7 cells, with an IC50 value of 30.6 ± 4.3 µM.

Palavras-chave

Croton yanhuii Y. T. Chang; ECD calculations; Euphorbiaceae; NO inhibitory activity; cembranoids

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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