[Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration].
Rinsho Ketsueki
; 64(1): 18-22, 2023.
Article
em Ja
| MEDLINE
| ID: mdl-36775301
ABSTRACT
A 51-year-old man with the chief complaint of glove- and stocking-type dysesthesia for >3 years was diagnosed with Waldenström's macroglobulinemia (WM) based on IgM-type M-proteinemia, bone marrow infiltration of plasmacytoid B cells, multiple lymphadenopathies, and splenomegaly. A nerve conduction examination suggested demyelinating neuropathy. Serum anti-myelin-associated glycoprotein antibody was negative. Sural nerve biopsy showed myelin thinning, suggesting demyelination. Axonal damage and tumor cell infiltration in the intrafascicular epineurium were also observed. After chemotherapies with rituximab and bendamustine, M-proteinemia and lymphadenopathies disappeared. However, abnormalities in the nerve conduction examination and dysesthesia were only slightly alleviated. As articles describing patients with WM with peripheral nerve infiltration are limited, we report this case with a literature review.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Macroglobulinemia de Waldenstrom
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Doenças do Sistema Nervoso Periférico
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Linfadenopatia
Limite:
Humans
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Male
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Middle aged
Idioma:
Ja
Revista:
Rinsho Ketsueki
Ano de publicação:
2023
Tipo de documento:
Article