A nitric oxide responsive AIE probe for detecting the progression of osteoarthritis.
J Mater Chem B
; 11(10): 2145-2156, 2023 03 08.
Article
em En
| MEDLINE
| ID: mdl-36776022
ABSTRACT
Nitric oxide (NO) is reported to be elevated in osteoarthritis (OA) both in vitro and in vivo and may be adopted to develop fluorescent probes for detecting the progression of OA. Here we report a nitric oxide responsive aggregation induced emission (AIE) probe TPE-2NHCOCH2CH2-(PEG)24-NH-Diacerein, which is derived from tetraphenylethene (TPE) modified with the hydrophilic group long poly(ethylene glycol) chain and an anti-inflammatory drug diacerein. o-Phenylenediamine within its structure can react with NO to form benzotriazole and emit fluorescence. The results show that the NO-responsive AIE probe can smartly monitor the progression of OA with the change of fluorescence intensity in vitro and in vivo. This study may provide a new development direction for early OA monitoring in clinics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Óxido Nítrico
Idioma:
En
Revista:
J Mater Chem B
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China