Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation.

Cheng, Qi; Wu, Jing; Xia, Yingqian; Cheng, Qing; Zhao, Yinjuan; Zhu, Peixiang; Zhang, Wangling; Zhang, Shihu; Zhang, Lei; Yuan, Yushan; Li, Chaojun; Chen, Guiquan; Xue, Bin

Cheng, Qi; Wu, Jing; Xia, Yingqian; Cheng, Qing; Zhao, Yinjuan; Zhu, Peixiang; Zhang, Wangling; Zhang, Shihu; Zhang, Lei; Yuan, Yushan; Li, Chaojun; Chen, Guiquan; Xue, Bin.

Afiliação

Cheng Q; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China.
Wu J; Core Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China.
Xia Y; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China.
Cheng Q; Department of Obstetrics, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210004, Jiangsu, China.
Zhao Y; Collaborative Innovation Center of Sustainable Forestry in Southern China, College of Forestry, Nanjing Forestry University, Nanjing, 210037, Jiangsu, China.
Zhu P; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China.
Zhang W; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China.
Zhang S; Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.
Zhang L; Medical Imaging Center of Fuyang People's Hospital, Fuyang, Anhui Province, China.
Yuan Y; Medical Imaging Center of Fuyang People's Hospital, Fuyang, Anhui Province, China.
Li C; State Key Laboratory of Reproductive Medicine and China International Joint Research Center On Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. lichaojun@njmu.edu.cn.
Chen G; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China. chenguiquan@nju.edu.cn.
Xue B; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. chenguiquan@nju.edu.cn.

Mol Brain ; 16(1): 24, 2023 02 13.

Article em En | MEDLINE | ID: mdl-36782228

Assuntos

Células-Tronco Neurais; Prenilação de Proteína; Camundongos; Animais; Cerebelo; Ataxia; Proliferação de Células; Camundongos Knockout

Palavras-chave

Ataxia; Cerebellum; Ggpps; Proliferation; Protein prenylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prenilação de Proteína / Células-Tronco Neurais Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Mol Brain Assunto da revista: BIOLOGIA MOLECULAR / CEREBRO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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