Recent Advancements in Gremlin-1: Breast cancer.
J Pak Med Assoc
; 73(Suppl 1)(2): S155-S159, 2023 Feb.
Article
em En
| MEDLINE
| ID: mdl-36788408
ABSTRACT
One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or -independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Peptídeos e Proteínas de Sinalização Intercelular
Limite:
Female
/
Humans
Idioma:
En
Revista:
J Pak Med Assoc
Ano de publicação:
2023
Tipo de documento:
Article