&#945;-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-&#954;B pathway in Schwann cells of vagus nerve in a rat model.

Cheng, Yue; Tong, Qing; Yuan, Yongsheng; Song, Xinna; Jiang, Wenwen; Wang, Yueping; Li, Wenjie; Li, Yangxia; Zhang, Kezhong

α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.

Cheng, Yue; Tong, Qing; Yuan, Yongsheng; Song, Xinna; Jiang, Wenwen; Wang, Yueping; Li, Wenjie; Li, Yangxia; Zhang, Kezhong.

Afiliação

Cheng Y; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Tong Q; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yuan Y; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Song X; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Jiang W; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Wang Y; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Li W; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Li Y; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Zhang K; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. kezhong_zhang1969@126.com.

J Neuroinflammation ; 20(1): 36, 2023 Feb 14.

Article em En | MEDLINE | ID: mdl-36788559

Assuntos

Doença de Parkinson; Ratos; Humanos; Animais; Doença de Parkinson/patologia; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo; NF-kappa B/metabolismo; Fator 88 de Diferenciação Mieloide/genética; Fator 88 de Diferenciação Mieloide/metabolismo; Receptor 2 Toll-Like/genética; Receptor 2 Toll-Like/metabolismo; Sintomas Prodrômicos; Nervo Vago/fisiologia; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Células de Schwann/metabolismo; Modelos Animais de Doenças

Palavras-chave

Autonomic dysfunction; Neuroinflammation; Parkinson's disease; Prodromal phase; Schwann cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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