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Predictive value of modified MRI-based split scar sign (mrSSS) score for pathological complete response after neoadjuvant chemoradiotherapy for patients with rectal cancer.
Yuan, Yuan; Zheng, Kuo; Zhou, Lu; Chen, Fangying; Zhang, Shaoting; Lu, Haidi; Lu, Jianping; Shao, Chengwei; Meng, Ronggui; Zhang, Wei; Gao, Xianhua; Shen, Fu.
Afiliação
  • Yuan Y; Department of Radiology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Zheng K; Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Zhou L; Hereditary Colorectal Cancer Center and Genetic Block Center of Familial Cancer, Changhai Hospital, Shanghai, China.
  • Chen F; Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Zhang S; Hereditary Colorectal Cancer Center and Genetic Block Center of Familial Cancer, Changhai Hospital, Shanghai, China.
  • Lu H; Department of Radiology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Lu J; Department of Radiology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Shao C; Department of Radiology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Meng R; Department of Radiology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Zhang W; Department of Radiology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Gao X; Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
  • Shen F; Hereditary Colorectal Cancer Center and Genetic Block Center of Familial Cancer, Changhai Hospital, Shanghai, China.
Int J Colorectal Dis ; 38(1): 40, 2023 Feb 15.
Article em En | MEDLINE | ID: mdl-36790595
PURPOSE: To measure the diagnostic performance of modified MRI-based split scar sign (mrSSS) score for the prediction of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) for patients with rectal cancer. METHODS: The modified MRI-based split scar sign (mrSSS) score, which consists of T2-weighted images (T2WI)-based score and diffusion-weighted images (DWI)-based score. The sensitivity, specificity, and accuracy of modified mrSSS score, endoscopic gross type, and MRI-based tumor regression grading (mrTRG) score, in the prediction of pCR, were compared. The prognostic value of the modified mrSSS score was also studied. RESULTS: A total of 189 patients were included in the study. The Kendall's coefficient of interobserver concordance of modified mrSSS score, T2WI -based score, and DWI-based score were 0.899, 0.890, and 0.789 respectively. And the maximum and minimum k value of the modified mrSSS score was 0.797 (0.742-0.853) and 0.562 (0.490-0.634). The sensitivity, specificity, and accuracy of prediction of pCR were 0.66, 0.97, and 0.90 for modified mrSSS score; 0.37, 0.89, and 0.78 for endoscopic gross type (scar); and 0.24, 0.92, and 0.77 for mrTRG score (mrTRG = 1). The modified mrSSS score had significantly higher sensitivity than the endoscopic gross type and the mrTRG score in predicting pCR. Patients with lower modified mrSSS scores had significantly longer disease-free survival (P < 0.05). CONCLUSION: The modified mrSSS score showed satisfactory interobserver agreement and higher sensitivity in predicting pCR after nCRT in patients with rectal cancer. The modified mrSSS score is also a predictor of disease-free survival.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Terapia Neoadjuvante Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Colorectal Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Terapia Neoadjuvante Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Colorectal Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Alemanha