Research on Diagnostic Markers for Post-Stroke Cognitive Impairment.

Objective: Post-stroke cognitive impairment (PSCI) is secondary to stroke, and is a significant burden for patients, their families and society as a whole. Our study aimed to investigate the predictive value of ß-amyloid 42 (Aß42) and hemoglobin (Hb) in the diagnosis of PSCI. Methods: 120 patients were selected and then assigned to either the PSCI group, Alzheimer's disease (AD) group or post-stroke cognitive normal (PSCN) group. Baseline data were recorded. Correlation between Aß42 and Hb and cognitive scores was evaluated. Then, the ability of these indicators to predict PSCI was compared based on logistic regression analysis and ROC curve. Results: Aß42 and Hb in the PSCI group were lower than in the AD and PSCN groups (P < .05). Compared with AD, hypertension (HTN) and Hb were independent risk factors for PSCI (P < .05), and Aß42 was a relevant risk factor for PSCI (P = .063). Compared with PSCN, age and Hb posed a threat to the occurrence of PSCI (P < .05). Under the ROC curve, the area under the curve (AUC) of the joint diagnosis of Aß42 and Hb was 0.7169, specificity was 0.625 and sensitivity reached 0.800. Conclusion: Aß42 and Hb in patients with PSCI were significantly lower than in the AD and PSCN groups, and were risk factors for PSCI. When the two are combined, the differential diagnosis performance may be improved.