Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis.

Shi, Fu-Li; Yuan, Li-Sha; Wong, Tak-Sui; Li, Qing; Li, Ya-Ping; Xu, Rong; You, Yi-Ping; Yuan, Tao; Zhang, Hong-Rui; Shi, Zi-Jian; Zha, Qing-Bing; Hu, Bo; He, Xian-Hui; Ouyang, Dong-Yun

Shi, Fu-Li; Yuan, Li-Sha; Wong, Tak-Sui; Li, Qing; Li, Ya-Ping; Xu, Rong; You, Yi-Ping; Yuan, Tao; Zhang, Hong-Rui; Shi, Zi-Jian; Zha, Qing-Bing; Hu, Bo; He, Xian-Hui; Ouyang, Dong-Yun.

Afiliação

Shi FL; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Yuan LS; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Wong TS; Department of Nephrology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Li Q; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Li YP; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Xu R; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
You YP; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Yuan T; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Zhang HR; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Shi ZJ; Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Zha QB; Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Jinan University, Heyuan 517000, China.
Hu B; Department of Nephrology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China. Electronic address: 42089537@qq.com.
He XH; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Jinan University, Heyuan 517000, China. Electronic address: thexh@jnu.edu.cn.
Ouyang DY; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address: dongyun1967@aliyun.com.

Pharmacol Res ; 189: 106697, 2023 03.

Article em En | MEDLINE | ID: mdl-36796462

Assuntos

Proteínas Quinases; Fator de Necrose Tumoral alfa; Camundongos; Animais; Fator de Necrose Tumoral alfa/metabolismo; Proteínas Quinases/metabolismo; Fumarato de Dimetilo; Necroptose; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo; Síndrome de Resposta Inflamatória Sistêmica; Fosforilação Oxidativa; Apoptose

Palavras-chave

Antimycin A (PubChem CID: 14957); Dimethyl fumarate; Dimethyl fumarate (PubChem CID: 637568); Dimethyl malonate (PubChem CID: 7943); Dimethyl succinate (PubChem CID: 7820); GSK'872 (PubChem CID: 54674134); MLKL; Monomethyl fumarate (PubChem CID: 5369209); N-acetyl-L-cysteine (PubChem CID: 12035); Necroptosis; Necrostatin-1 (PubChem CID: 2828334); RIPK3; Reverse electron transport; Rotenone (PubChem CID: 6758); Systemic inflammatory response syndrome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Fator de Necrose Tumoral alfa Limite: Animals Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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